Key takeaways
- Some medical conditions and medications can cause the same symptoms as depression or anxiety, which is why a full psychiatric evaluation asks about physical health.
- Examples with published evidence: thyroid disorders, vitamin B12 deficiency, obstructive sleep apnea, and long-term poor sleep.
- These are associations, not self-diagnoses. Do not start supplements or stop medication on your own. Ask your clinician whether testing makes sense for you.
- Finding a physical contributor does not mean your symptoms are “not real.” It means treatment may need to address more than one thing.
Feeling low, wired or unable to focus does not always start in the mind. Sometimes it starts in the thyroid, in a vitamin level, in sleep, or in a medication. A thorough psychiatric evaluation therefore looks at the body as well as the story. This guide explains what the research says, without telling you to diagnose yourself.
Why does a psychiatric evaluation ask about physical health?
The American Psychiatric Association says a mental health diagnosis typically involves a full health evaluation, which can include a physical exam and sometimes blood work or neurological tests, because some conditions mimic medical problems (APA (opens in a new tab)). The National Institute of Mental Health notes that certain medications and medical conditions, such as viruses or thyroid disorders, can cause the same symptoms as depression (NIMH (opens in a new tab)). MedlinePlus adds that medical tests may be done to rule out other conditions (MedlinePlus (opens in a new tab)).
That is one of the three lenses in Better Place Now’s approach. The “body” lens looks at sleep, lab work, nutrition, medical history and every medication already in the picture. You can read more about the framework in what integrative psychiatry is.
Thyroid problems and mood
NIMH lists hypothyroidism among the chronic diseases linked with depression. The link runs both ways, and depression together with a chronic illness tends to produce more severe symptoms of both (NIMH (opens in a new tab)). A blood test can check thyroid function, which is one reason lab work is part of a careful evaluation.
Vitamin B12 deficiency
The National Heart, Lung, and Blood Institute explains that untreated vitamin B12 deficiency can cause confusion, forgetfulness and mood changes such as depression or irritability (NHLBI (opens in a new tab)). MedlinePlus describes irritability, reduced concentration and confusion with prolonged deficiency, and psychosis in severe cases (MedlinePlus (opens in a new tab)). If you suspect a deficiency, ask for a blood test rather than guessing with supplements.
Sleep apnea, insomnia and poor sleep
A meta-analysis of 73 articles found depressive symptoms in about 35% and anxious symptoms in about 32% of people with obstructive sleep apnea. This is an association, and the authors suggest it runs both ways (Garbarino et al., 2020 (opens in a new tab)). Insomnia also matters. A meta-analysis of 13 longitudinal studies found that insomnia predicted later depression (odds ratio 2.83) and anxiety (odds ratio 3.23) (Hertenstein et al., 2019 (opens in a new tab)).
For general guidance, the CDC says adults aged 18 to 60 need seven or more hours of sleep, and that adequate sleep can reduce stress and improve mood (CDC (opens in a new tab)). If snoring, gasping at night or daytime exhaustion is part of the picture, tell your clinician. Treating sleep can change how everything else feels.
Conditions that overlap with ADHD
MedlinePlus explains that there is no single test for ADHD, and that clinicians must rule out other conditions such as anxiety or depression (MedlinePlus (opens in a new tab)). Poor sleep and anxiety can also cause trouble focusing. That is why an ADHD evaluation asks about sleep, mood, anxiety and health before settling on an answer. See ADHD evaluation by telehealth in Arizona for how it works.
| What the source says | What to do | |
|---|---|---|
| Thyroid disorders | Can cause symptoms like depression; hypothyroidism is linked with depression (NIMH) | Ask whether thyroid testing makes sense for you |
| Vitamin B12 deficiency | Untreated, can cause confusion and mood changes such as depression or irritability (NHLBI) | Ask about a blood test before taking supplements |
| Obstructive sleep apnea | Depressive symptoms in about 35% and anxious symptoms in about 32% of people with it (meta-analysis) | Mention snoring, gasping or daytime exhaustion |
| Insomnia and short sleep | Predicts later depression and anxiety (meta-analysis) | Track sleep and discuss it at your visit |
| Medications | Certain medications can cause depression-like symptoms (NIMH, MedlinePlus) | Bring a full list, including supplements |
What to bring to the visit
- Every medication and supplement, with doses. Include over-the-counter products.
- Recent lab results, if you have them, and the name of your primary care clinician.
- Sleep notes: bedtime, wake time, snoring, night-time waking, how rested you feel.
- Symptoms with dates, including anything that changed around the same time.
- Questions. For example, “Could anything physical be contributing to this?”
For what happens in a full first hour, see what to expect at your first psychiatry visit. If you are ready to talk it through, you can request an appointment.
Common questions
Can a thyroid problem cause anxiety or depression?
Thyroid disorders can cause symptoms that look like depression, and NIMH lists hypothyroidism among the chronic diseases linked with depression. A blood test can check thyroid function, so ask your clinician whether it makes sense for you.
Will Better Place Now order lab work?
A thoughtful evaluation can consider lab work alongside sleep, nutrition, medical history, stress and current medications. What is appropriate depends on your situation.
Should I take supplements to fix this?
Do not start supplements on your own. If a deficiency is suspected, a blood test can confirm it, and your clinician can advise what is appropriate.
If a physical cause is found, are my symptoms not real?
No. Symptoms are real whatever their cause. Finding a physical contributor simply means treatment may need to address more than one thing.
Sources
- What is mental illness? (opens in a new tab). American Psychiatric Association, 2025.
- Depression (opens in a new tab). National Institute of Mental Health, 2024.
- Depression (opens in a new tab). MedlinePlus, U.S. National Library of Medicine, 2025.
- Understanding the link between chronic disease and depression (opens in a new tab). National Institute of Mental Health, 2024.
- Vitamin B12 deficiency anemia (opens in a new tab). National Heart, Lung, and Blood Institute, 2022.
- Vitamin B12 deficiency anemia (opens in a new tab). MedlinePlus, U.S. National Library of Medicine, 2026.
- Association of anxiety and depression with obstructive sleep apnea (opens in a new tab). Garbarino et al., Behavioral Sleep Medicine, 2020.
- Insomnia as a predictor of mental disorders: a systematic review and meta-analysis (opens in a new tab). Hertenstein et al., Sleep Medicine Reviews, 2019.
- About sleep (opens in a new tab). Centers for Disease Control and Prevention, 2024.
- Attention deficit hyperactivity disorder (opens in a new tab). MedlinePlus, U.S. National Library of Medicine, 2023.




